BET bromodomain inhibitor JQ1 regulates spermatid development by changing chromatin conformation in mouse spermatogenesis

As a BET bromodomain inhibitor, JQ1 has been proven have efficacy against a number of different cancers. In terms of male reproduction, JQ1 may be used as a new type of contraceptive, since JQ1 treatment in male mice could lead to germ cell defects and a decrease of sperm motility, moreover, this ef...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Xiaorong, Sang, Mengmeng, Gong, Shengnan, Chen, Zhichuan, Zhao, Xi, Wang, Guishuan, Li, Zhiran, Huang, Yingying, Chen, Shitao, Xie, Gangcai, Duan, Enkui, Sun, Fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chongqing Medical University 2021
Materias:
Full Length Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9170580/
https://www.ncbi.nlm.nih.gov/pubmed/35685458
http://dx.doi.org/10.1016/j.gendis.2020.12.012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9170580/
https://www.ncbi.nlm.nih.gov/pubmed/35685458
http://dx.doi.org/10.1016/j.gendis.2020.12.012

Ejemplares similares