Cargando…

ADSC-Exosomes Alleviate MTX-induced Rat Neuronal Damage by Activating Nrf2-ARE Pathway

The aim of this study was to analyze the efficacy and underlying mechanism of adipose-derived mesenchymal stem cell exosome (ADSC-exosomes)–mediated protection on methotrexate (MTX)–induced neuronal damage. We established a H(2)O(2)induced oxidative stress model in vitro, as well as an MTX-induced...

Descripción completa

Detalles Bibliográficos
Autores principales:	Huang, Tingting, Tong, Hongfei, Zhou, Haixia, Wang, Juxiang, Hu, Linglong, Wang, Yao, Huang, Zhen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9170627/ https://www.ncbi.nlm.nih.gov/pubmed/35322376 http://dx.doi.org/10.1007/s12031-022-01996-x

Ejemplares similares

Application of ADSCs and their Exosomes in Scar Prevention
por: Li, Cong, et al.
Publicado: (2021)

ADSC Exosomes Mediate lncRNA-MIAT Alleviation of Endometrial Fibrosis by Regulating miR-150-5p
por: Shao, Xiaowen, et al.
Publicado: (2021)

Study on Exosomes Promoting the Osteogenic Differentiation of ADSCs in Graphene Porous Titanium Alloy Scaffolds
por: Sun, Xu, et al.
Publicado: (2022)

Treatment of methotrexate (MTX) intolerance: behavioural therapy, versus switch to parenteral MTX versus oral MTX
por: Verkaaik, M, et al.
Publicado: (2011)

Identification and characterization of hADSC‐derived exosome proteins from different isolation methods
por: Huang, Lien‐Hung, et al.
Publicado: (2021)

Exosomes from SIRT1-Overexpressing ADSCs Restore Cardiac Function by Improving Angiogenic Function of EPCs
por: Huang, Hui, et al.
Publicado: (2020)

ADSC-derived exosomes attenuate myocardial infarction injury by promoting miR-205-mediated cardiac angiogenesis
por: Wang, Tingting, et al.
Publicado: (2023)

Methotrexate (MTX) Plus Hydroxychloroquine versus MTX Plus Leflunomide in Patients with MTX-Resistant Active Rheumatoid Arthritis: A 2-Year Cohort Study in Real World
por: Zhang, Le, et al.
Publicado: (2020)

Rebuilding hippocampus neural circuit with hADSC-derived neuron cells for treating ischemic stroke
por: Wang, Jian, et al.
Publicado: (2022)

Monoclonal antibody targeting of methotrexate (MTX) against MTX-resistant tumour cell lines.
por: Affleck, K., et al.
Publicado: (1992)

Impairment of Methotrexate (MTX)‐Polyglutamate Formation of MTX‐resistant K562 Cell Lines
por: Koizumi, Shoichi
Publicado: (1988)

ML-13 AN ATTEMPT OF RECHALLENGE OF HD-MTX AND MAINTENANCE THERAPY OF MTX FOR PATIENTS WITH PCNSL
por: Yamaguchi, Takashi, et al.
Publicado: (2019)

Combined topical and systemic administration with human adipose-derived mesenchymal stem cells (hADSC) and hADSC-derived exosomes markedly promoted cutaneous wound healing and regeneration
por: Zhou, Yang, et al.
Publicado: (2021)

Melatonin Alleviates Neuronal Damage After Intracerebral Hemorrhage in Hyperglycemic Rats
por: Liang, Feng, et al.
Publicado: (2020)

GSTM2 alleviates heart failure by inhibiting DNA damage in cardiomyocytes
por: Xu, Hongfei, et al.
Publicado: (2023)

Implementation of an Outpatient HD-MTX Initiative
por: Sokol, Kelsey, et al.
Publicado: (2022)

Exosomes from Adipose-Derived Stem Cells (ADSCs) Overexpressing miR-21 Promote Vascularization of Endothelial Cells
por: An, Yang, et al.
Publicado: (2019)

The Therapeutic Role of ADSC-EVs in Skin Regeneration
por: Wang, Yixi, et al.
Publicado: (2022)

How to Get the Most from Methotrexate (MTX) Treatment for Your Rheumatoid Arthritis Patient?—MTX in the Treat-to-Target Strategy
por: Taylor, Peter. C., et al.
Publicado: (2019)

Pragmatic randomised controlled trial of very early etanercept and MTX versus MTX with delayed etanercept in RA: the VEDERA trial
por: Emery, Paul, et al.
Publicado: (2020)

Age-related alteration in characteristics, function, and transcription features of ADSCs
por: Li, Keya, et al.
Publicado: (2021)

Exosomes From miR-19b-3p-Modified ADSCs Inhibit Ferroptosis in Intracerebral Hemorrhage Mice
por: Yi, Xia, et al.
Publicado: (2021)

GO-DACT: a phase 3b randomised, double-blind, placebo-controlled trial of GOlimumab plus methotrexate (MTX) versus placebo plus MTX in improving DACTylitis in MTX-naive patients with psoriatic arthritis
por: Vieira-Sousa, Elsa, et al.
Publicado: (2020)

Experimental research on ADSCs-NCSS in wound repair
por: Zhang, Ai-Jun, et al.
Publicado: (2018)

MTX-211 Inhibits GSH Synthesis through Keap1/NRF2/GCLM Axis and Exerts Antitumor Effects in Bladder Cancer
por: Hu, Bing, et al.
Publicado: (2023)

Relationship between clinical and patient-reported outcomes in a phase 3 trial of tofacitinib or MTX in MTX-naïve patients with rheumatoid arthritis
por: Fleischmann, Roy, et al.
Publicado: (2016)

Monitoring Of High-Dose Methotrexate (Mtx)-Related Toxicity and Mtx Levels in Children with Acute Lymphoblastic Leukemia: A Pilot-Study in Indonesia
por: Sari, Nur Melani, et al.
Publicado: (2021)

Downregulation of TNFAIP1 alleviates OGD/R‑induced neuronal damage by suppressing Nrf2/GPX4‑mediated ferroptosis
por: Xiong, Lie, et al.
Publicado: (2022)

Complete Genome Sequence of Serratia marcescens Phage MTx
por: Graham, Kristin, et al.
Publicado: (2019)

MicroRNA-221/222 Mediates ADSC-Exosome-Induced Cardioprotection Against Ischemia/Reperfusion by Targeting PUMA and ETS-1
por: Lai, Tsai-Chun, et al.
Publicado: (2020)

Effects of cytochrome P450 family 3 subfamily A member 5 gene polymorphisms on daunorubicin metabolism and adverse reactions in patients with acute leukemia
por: Huang, Zhen, et al.
Publicado: (2017)

ADSCs-derived exosomes ameliorate hepatic fibrosis by suppressing stellate cell activation and remodeling hepatocellular glutamine synthetase-mediated glutamine and ammonia homeostasis
por: Wu, Baitong, et al.
Publicado: (2022)

Temporary Upregulation of Nrf2 by Naringenin Alleviates Oxidative Damage in the Retina and ARPE-19 Cells
por: Chen, Wenpei, et al.
Publicado: (2021)

Cancer‐associated fibroblast‐derived exosomal microRNA‐24‐3p enhances colon cancer cell resistance to MTX by down‐regulating CDX2/HEPH axis
por: Zhang, Hong‐Wei, et al.
Publicado: (2021)

The Duo of Osteogenic and Angiogenic Differentiation in ADSC-Derived Spheroids
por: Gorkun, Anastasiya A., et al.
Publicado: (2021)

Biomaterials combined with ADSCs for bone tissue engineering: current advances and applications
por: Song, Yiping, et al.
Publicado: (2023)

Mid-board miniature dual channel optical transmitter MTx and transceiver MTRx
por: Zhao, Xiandong, et al.
Publicado: (2020)

Predictors and clinical features of methotrexate (MTX) therapy for ectopic pregnancy
por: Zhang, Jing, et al.
Publicado: (2020)

Association Between White Blood Cells at Baseline and Treatment Failure of MTX for Ectopic Pregnancy
por: Chen, Si, et al.
Publicado: (2021)

Neurons-derived extracellular vesicles promote neural differentiation of ADSCs: a model to prevent peripheral nerve degeneration
por: Roballo, Kelly Cristine Santos, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_5trqadd7nasver5l6h3iom038e