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Increased mTORC2 pathway activation in lymph nodes of iMCD‐TAFRO

Idiopathic multicentric Castleman disease (iMCD) is a rare and life‐threatening haematologic disorder involving polyclonal lymphoproliferation and organ dysfunction due to excessive cytokine production, including interleukin‐6 (IL‐6). Clinical trial and real‐world data demonstrate that IL‐6 inhibiti...

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Detalles Bibliográficos
Autores principales: Phillips, Alexis D., Kakkis, Joseph J., Tsao, Patricia Y., Pierson, Sheila K., Fajgenbaum, David C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9170805/
https://www.ncbi.nlm.nih.gov/pubmed/35488725
http://dx.doi.org/10.1111/jcmm.17251