Blocking P2X7 receptor with AZ 10606120 exacerbates vascular hyperpermeability and inflammation in murine polymicrobial sepsis

Sepsis is a devastating disease with high morbidity and mortality and no specific treatments. The pathophysiology of sepsis involves a hyperinflammatory response and release of damage‐associated molecular patterns (DAMPs), including adenosine triphosphate (ATP), from activated and dying cells. Purin...

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Detalles Bibliográficos
Autores principales: Meegan, Jamie E., Komalavilas, Padmini, Cheung‐Flynn, Joyce, Yim, Tsz Wing, Putz, Nathan D., Jesse, Jordan J., Smith, Kyle D., Sidorova, Tatiana N., Lee, Han Noo Ri, Tomasek, Toria, Shaver, Ciara M., Ware, Lorraine B., Brophy, Colleen M., Bastarache, Julie A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9170948/
https://www.ncbi.nlm.nih.gov/pubmed/35668576
http://dx.doi.org/10.14814/phy2.15290

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9170948/
https://www.ncbi.nlm.nih.gov/pubmed/35668576
http://dx.doi.org/10.14814/phy2.15290

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