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Dentate Granule Cells Are Hyperexcitable in the TgF344-AD Rat Model of Alzheimer's Disease

The dentate gyrus is both a critical gatekeeper for hippocampal signal processing and one of the first brain regions to become dysfunctional in Alzheimer's disease (AD). Accordingly, the appropriate balance of excitation and inhibition through the dentate is a compelling target for mechanistic...

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Detalles Bibliográficos
Autores principales: Smith, Lindsey A., Goodman, Anthoni M., McMahon, Lori L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9171068/
https://www.ncbi.nlm.nih.gov/pubmed/35685246
http://dx.doi.org/10.3389/fnsyn.2022.826601