Cargando…

Early empiric anti-Mycobacterium tuberculosis therapy for sepsis in sub-Saharan Africa: a protocol of a randomised clinical trial

INTRODUCTION: Sub-Saharan Africa shoulders the highest burden of global sepsis and associated mortality. In high HIV and tuberculosis (TB) prevalent settings such as sub-Saharan Africa, TB is the leading cause of sepsis. However, anti-TB therapy is often delayed and may not achieve adequate blood co...

Descripción completa

Detalles Bibliográficos
Autores principales:	Said, Bibie, Nuwagira, Edwin, Liyoyo, Alphonce, Arinaitwe, Rinah, Gitige, Catherine, Mushagara, Rhina, Buzaare, Peter, Chongolo, Anna, Jjunju, Samuel, Twesigye, Precious, Boulware, David R, Conaway, Mark, Null, Megan, Thomas, Tania A, Heysell, Scott K, Moore, Christopher C, Muzoora, Conrad, Mpagama, Stellah G
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2022
Materias:	Infectious Diseases
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9171283/ https://www.ncbi.nlm.nih.gov/pubmed/35667721 http://dx.doi.org/10.1136/bmjopen-2022-061953

Ejemplares similares

Is Sub-Saharan Africa prepared for COVID-19?
por: Nuwagira, Edwin, et al.
Publicado: (2020)

Persistently elevated intracranial pressure in cryptococcal meningitis– 76 therapeutic lumbar punctures
por: Jjunju, Samuel, et al.
Publicado: (2023)

Burden, clinical features and outcomes of post-tuberculosis lung disease in sub-Saharan Africa: a protocol for a systematic review and meta-analysis
por: Nuwagira, Edwin, et al.
Publicado: (2022)

Gridlock from Diagnosis to Treatment of Multidrug-Resistant Tuberculosis (MDR-TB) in Tanzania: Illuminating Potential Factors for Possible Intervention
por: Liyoyo, Alphonce A, et al.
Publicado: (2017)

Pharmacodynamic Biomarkers for Quantifying the Mycobacterial Effect of High Doses of Rifampin in Patients with Rifampin-susceptible Pulmonary Tuberculosis
por: Said, Bibie N, et al.
Publicado: (2021)

Gridlock from diagnosis to treatment of multidrug-resistant tuberculosis in Tanzania: low accessibility of molecular diagnostic services and lack of healthcare worker empowerment in 28 districts of 5 high burden TB regions with mixed methods evaluation
por: Mpagama, Stellah G., et al.
Publicado: (2019)

Decision Analytic Modeling for Global Clinical Trial Planning: A Case for HIV-Positive Patients at High Risk for Mycobacterium tuberculosis Sepsis in Uganda
por: Keim-Malpass, Jessica, et al.
Publicado: (2023)

Gridlock from diagnosis to treatment of multidrug resistant tuberculosis (MDR-TB) in Tanzania: patients’ perspectives from a focus group discussion
por: Mpagama, Stellah G., et al.
Publicado: (2020)

Protocol for a feasibility randomized controlled trial to evaluate the efficacy, safety and tolerability of N-acetylcysteine in reducing adverse drug reactions among adults treated for multidrug-resistant tuberculosis in Tanzania
por: Mpagama, Stellah G., et al.
Publicado: (2023)

Underestimated pyrazinamide resistance may compromise outcomes of pyrazinamide containing regimens for treatment of drug susceptible and multi-drug-resistant tuberculosis in Tanzania
por: Juma, Saumu Pazia, et al.
Publicado: (2019)

Implementing Innovative Approaches to Improve Health Care Delivery Systems for Integrating Communicable and Non-Communicable Diseases Using Tuberculosis and Diabetes as a Model in Tanzania
por: Mpagama, Stellah G., et al.
Publicado: (2023)

Silicosis, tuberculosis and silica exposure among artisanal and small-scale miners: A systematic review and modelling paper
por: Howlett, Patrick, et al.
Publicado: (2023)

Population Pharmacokinetics and Significant Under-Dosing of Anti-Tuberculosis Medications in People with HIV and Critical Illness
por: Rao, Prakruti S., et al.
Publicado: (2021)

Coinfection of COVID-19 and Tuberculosis in Uganda
por: Nuwagira, Edwin, et al.
Publicado: (2023)

Determination of plasma concentrations of levofloxacin by high performance liquid chromatography for use at a multidrug-resistant tuberculosis hospital in Tanzania
por: Ebers, Andrew, et al.
Publicado: (2017)

AMBIsome Therapy Induction OptimisatioN (AMBITION): High dose AmBisome for cryptococcal meningitis induction therapy in sub-Saharan Africa: economic evaluation protocol for a randomised controlled trial-based equivalence study
por: Ponatshego, Ponego Lloyd, et al.
Publicado: (2019)

Prospective evaluation of improving fluoroquinolone exposure using centralised therapeutic drug monitoring (TDM) in patients with tuberculosis (PERFECT): a study protocol of a prospective multicentre cohort study
por: van den Elsen, Simone HJ, et al.
Publicado: (2020)

Diagnostic Opportunities for Optimizing Management of Multidrug-Resistant Tuberculosis (MDR-TB) in Tanzania
por: Mpagama, Stellah G
Publicado: (2018)

Diagnostic and Prognostic Value of Cerebrospinal Fluid Lactate and Glucose in HIV-Associated Tuberculosis Meningitis
por: Nuwagira, Edwin, et al.
Publicado: (2022)

Application of quantitative second-line drug susceptibility testing at a multidrug-resistant tuberculosis hospital in Tanzania
por: Mpagama, Stellah G, et al.
Publicado: (2013)

Evaluation of cytokines in peripheral blood mononuclear cell supernatants for the diagnosis of tuberculosis
por: Sariko, Margaretha, et al.
Publicado: (2018)

Blood neutrophil counts in HIV-infected patients with cryptococcal meningitis: Association with mortality
por: Musubire, Abdu Kisekka, et al.
Publicado: (2018)

Multiple Pathogens Contribute to Human Immunodeficiency Virus-Related Sepsis in Addition to Mycobacterium tuberculosis: A Prospective Cohort in Tanzania
por: Tsere, Donatus Bonphace, et al.
Publicado: (2022)

Association of Hyponatremia on Mortality in Cryptococcal Meningitis: A Prospective Cohort
por: Tugume, Lillian, et al.
Publicado: (2022)

Evaluation of the Antibody in Lymphocyte Supernatant Assay to Detect Active Tuberculosis
por: Sariko, Margaretha, et al.
Publicado: (2017)

A mobile microvolume UV/visible light spectrophotometer for the measurement of levofloxacin in saliva
por: Alffenaar, Jan-Willem C, et al.
Publicado: (2020)

TB or not TB? Definitive determination of species within the M ycobacterium tuberculosis complex in unprocessed sputum from adults with presumed multidrug‐resistant tuberculosis
por: Mbelele, Peter M., et al.
Publicado: (2021)

Pharmacokinetic-Pharmacodynamic Determinants of Clinical Outcomes for Rifampin-Resistant Tuberculosis: A Multisite Prospective Cohort Study
por: Heysell, Scott K, et al.
Publicado: (2022)

Comparison of Overnight Pooled and Standard Sputum Collection Method for Patients with Suspected Pulmonary Tuberculosis in Northern Tanzania
por: Mpagama, Stellah G., et al.
Publicado: (2012)

Meta-Narrative Review of Molecular Methods for Diagnosis and Monitoring of Multidrug-Resistant Tuberculosis Treatment in Adults
por: Mbelele, Peter M., et al.
Publicado: (2018)

Protocol for systematic review and meta-analysis of treatment success rate among adult patients with tuberculosis in sub-Saharan Africa
por: Izudi, Jonathan, et al.
Publicado: (2018)

Novel approach to estimate tuberculosis transmission in primary care clinics in sub-Saharan Africa: protocol of a prospective study
por: Zürcher, Kathrin, et al.
Publicado: (2020)

Treatment success rate among adult pulmonary tuberculosis patients in sub-Saharan Africa: a systematic review and meta-analysis
por: Izudi, Jonathan, et al.
Publicado: (2019)

Erratum to: The Changing Epidemiology of HIV-Associated Adult Meningitis, Uganda 2015–2017
por: Ellis, Jayne, et al.
Publicado: (2019)

The Changing Epidemiology of HIV-Associated Adult Meningitis, Uganda 2015–2017
por: Ellis, Jayne, et al.
Publicado: (2019)

An Unusual Case of Pulmonary Cryptococcus
por: Aslam, Hafiz M, et al.
Publicado: (2018)

Population Pharmacokinetics of Levofloxacin and Moxifloxacin, and the Probability of Target Attainment in Ethiopian Patients with Multidrug-Resistant Tuberculosis
por: Sidamo, Temesgen, et al.
Publicado: (2022)

Incidence and predictors of early loss to follow up among patients initiated on protease inhibitor-based second-line antiretroviral therapy in southwestern Uganda
por: Nuwagira, Edwin, et al.
Publicado: (2021)

Improvement in Plasma Drug Activity during the Early Treatment Interval among Tanzanian Patients with Multidrug-Resistant Tuberculosis
por: Ndusilo, Norah D., et al.
Publicado: (2015)

Coinfections of malaria and sexually transmitted and reproductive tract infections in pregnancy in sub-Saharan Africa: a systematic review and individual participant data meta-analysis protocol
por: Sorano, Sumire, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_tr7687gb2qhr0pvg0gegv75la1