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Mechanisms of DNA damage‐mediated neurotoxicity in neurodegenerative disease

Neurons are highly susceptible to DNA damage accumulation due to their large energy requirements, elevated transcriptional activity, and long lifespan. While newer research has shown that DNA breaks and mutations may facilitate neuron diversity during development and neuronal function throughout lif...

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Detalles Bibliográficos
Autores principales: Welch, Gwyneth, Tsai, Li‐Huei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9171412/
https://www.ncbi.nlm.nih.gov/pubmed/35499251
http://dx.doi.org/10.15252/embr.202154217