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Heart-targeted amelioration of sepsis-induced myocardial dysfunction by microenvironment responsive nitric oxide nanogenerators in situ

BACKGROUND: A balanced endogenous level of bioavailable nitric oxide (NO) plays a key role in maintaining cardiovascular homeostasis. The bioactive NO level in the cardiomyocytes was much reduced during sepsis. However, it is clinically challenging for the NO gas therapy due to the lack of spatial a...

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Detalles Bibliográficos
Autores principales: Ouyang, Minzhi, Ouyang, Xiangnan, Peng, Zefang, Liu, Minghui, Xu, Ganqiong, Zou, Zhen, Zhang, Ming, Shang, Quanliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9171488/
https://www.ncbi.nlm.nih.gov/pubmed/35672697
http://dx.doi.org/10.1186/s12951-022-01457-y