Mechanism of tethered agonist-mediated signaling by polycystin-1

Polycystin-1 (PC1) is an important unusual G protein-coupled receptor (GPCR) with 11 transmembrane domains, and its mutations account for 85% of cases of autosomal dominant polycystic kidney disease (ADPKD). PC1 shares multiple characteristics with Adhesion GPCRs. These include a GPCR proteolysis si...

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Detalles Bibliográficos
Autores principales: Pawnikar, Shristi, Magenheimer, Brenda S., Munoz, Ericka Nevarez, Maser, Robin L., Miao, Yinglong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9171645/
https://www.ncbi.nlm.nih.gov/pubmed/35522707
http://dx.doi.org/10.1073/pnas.2113786119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9171645/
https://www.ncbi.nlm.nih.gov/pubmed/35522707
http://dx.doi.org/10.1073/pnas.2113786119

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