SHAPE-enabled fragment-based ligand discovery for RNA

The transcriptome represents an attractive but underused set of targets for small-molecule ligands. Here, we devise a technology that leverages fragment-based screening and SHAPE-MaP RNA structure probing to discover small-molecule fragments that bind an RNA structure of interest. We identified frag...

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Detalles Bibliográficos
Autores principales: Zeller, Meredith J., Favorov, Oleg, Li, Kelin, Nuthanakanti, Ashok, Hussein, Dina, Michaud, Auréliane, Lafontaine, Daniel A., Busan, Steven, Serganov, Alexander, Aubé, Jeffrey, Weeks, Kevin M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9171761/
https://www.ncbi.nlm.nih.gov/pubmed/35561226
http://dx.doi.org/10.1073/pnas.2122660119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9171761/
https://www.ncbi.nlm.nih.gov/pubmed/35561226
http://dx.doi.org/10.1073/pnas.2122660119

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