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Phenol-soluble modulins PSMα3 and PSMβ2 form nanotubes that are cross-α amyloids

Phenol-soluble modulins (PSMs) are peptide-based virulence factors that play significant roles in the pathogenesis of staphylococcal strains in community-associated and hospital-associated infections. In addition to cytotoxicity, PSMs display the propensity to self-assemble into fibrillar species, w...

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Detalles Bibliográficos
Autores principales: Kreutzberger, Mark A. B., Wang, Shengyuan, Beltran, Leticia C., Tuachi, Abraham, Zuo, Xiaobing, Egelman, Edward H., Conticello, Vincent P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9171771/
https://www.ncbi.nlm.nih.gov/pubmed/35533283
http://dx.doi.org/10.1073/pnas.2121586119