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Competing interactions give rise to two-state behavior and switch-like transitions in charge-rich intrinsically disordered proteins

The most commonly occurring intrinsically disordered proteins (IDPs) are polyampholytes, which are defined by the duality of low net charge per residue and high fractions of charged residues. Recent experiments have uncovered nuances regarding sequence–ensemble relationships of model polyampholytic...

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Detalles Bibliográficos
Autores principales: Zeng, Xiangze, Ruff, Kiersten M., Pappu, Rohit V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9171777/
https://www.ncbi.nlm.nih.gov/pubmed/35512095
http://dx.doi.org/10.1073/pnas.2200559119