SNAT7 regulates mTORC1 via macropinocytosis

Mammalian target of rapamycin complex 1 (mTORC1) senses amino acids to control cell growth, metabolism, and autophagy. Some amino acids signal to mTORC1 through the Rag GTPase, whereas glutamine and asparagine activate mTORC1 through a Rag GTPase-independent pathway. Here, we show that the lysosomal...

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Detalles Bibliográficos
Autores principales: Meng, Delong, Yang, Qianmei, Jeong, Mi-Hyeon, Curukovic, Adna, Tiwary, Shweta, Melick, Chase H., Lama-Sherpa, Tshering D., Wang, Huanyu, Huerta-Rosario, Mariela, Urquhart, Greg, Zacharias, Lauren G., Lewis, Cheryl, DeBerardinis, Ralph J., Jewell, Jenna L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9171778/
https://www.ncbi.nlm.nih.gov/pubmed/35561222
http://dx.doi.org/10.1073/pnas.2123261119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9171778/
https://www.ncbi.nlm.nih.gov/pubmed/35561222
http://dx.doi.org/10.1073/pnas.2123261119

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