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SNAT7 regulates mTORC1 via macropinocytosis
Mammalian target of rapamycin complex 1 (mTORC1) senses amino acids to control cell growth, metabolism, and autophagy. Some amino acids signal to mTORC1 through the Rag GTPase, whereas glutamine and asparagine activate mTORC1 through a Rag GTPase-independent pathway. Here, we show that the lysosomal...
Autores principales: | Meng, Delong, Yang, Qianmei, Jeong, Mi-Hyeon, Curukovic, Adna, Tiwary, Shweta, Melick, Chase H., Lama-Sherpa, Tshering D., Wang, Huanyu, Huerta-Rosario, Mariela, Urquhart, Greg, Zacharias, Lauren G., Lewis, Cheryl, DeBerardinis, Ralph J., Jewell, Jenna L. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9171778/ https://www.ncbi.nlm.nih.gov/pubmed/35561222 http://dx.doi.org/10.1073/pnas.2123261119 |
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