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Transsynaptic cerebellin 4–neogenin 1 signaling mediates LTP in the mouse dentate gyrus

Five decades ago, long-term potentiation (LTP) of synaptic transmission was discovered at entorhinal cortex→dentate gyrus (EC→DG) synapses, but the molecular determinants of EC→DG LTP remain largely unknown. Here, we show that the presynaptic neurexin–ligand cerebellin-4 (Cbln4) is highly expressed...

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Detalles Bibliográficos
Autores principales: Liakath-Ali, Kif, Polepalli, Jai S., Lee, Sung-Jin, Cloutier, Jean-Francois, Südhof, Thomas C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9171784/
https://www.ncbi.nlm.nih.gov/pubmed/35544694
http://dx.doi.org/10.1073/pnas.2123421119