Highly active CAR T cells that bind to a juxtamembrane region of mesothelin and are not blocked by shed mesothelin

Mesothelin (MSLN) is a cell-surface protein that is highly expressed by many cancers. Despite many clinical trials, there is not a Food and Drug Administration (FDA)-approved antibody-based therapy targeting MSLN. Shed MSLN is present in high concentrations in tumors and in body fluids and constitut...

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Detalles Bibliográficos
Autores principales: Liu, Xiufen, Onda, Masanori, Watson, Nathan, Hassan, Raffit, Ho, Mitchell, Bera, Tapan K., Wei, Junxia, Chakraborty, Anirban, Beers, Richard, Zhou, Qi, Shajahan, Asif, Azadi, Parastoo, Zhan, Jingyu, Xia, Di, Pastan, Ira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9171807/
https://www.ncbi.nlm.nih.gov/pubmed/35512094
http://dx.doi.org/10.1073/pnas.2202439119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9171807/
https://www.ncbi.nlm.nih.gov/pubmed/35512094
http://dx.doi.org/10.1073/pnas.2202439119

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