Ion-Pairing Chromatography and Amine Derivatization Provide Complementary Approaches for the Targeted LC-MS Analysis of the Polar Metabolome

[Image: see text] Liquid chromatography coupled to mass spectrometry is a key metabolomics/metabonomics technology. Reversed-phase liquid chromatography (RPLC) is very widely used as a separation step, but typically has poor retention of highly polar metabolites. Here, we evaluated the combination o...

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Detalles Bibliográficos
Autores principales: Sagi-Kiss, Virag, Li, Yufeng, Carey, Matthew R., Grover, Sarah J., Siems, Karsten, Cirulli, Francesca, Berry, Alessandra, Musillo, Chiara, Wilson, Ian D., Want, Elizabeth J., Bundy, Jacob G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9171846/
https://www.ncbi.nlm.nih.gov/pubmed/35536659
http://dx.doi.org/10.1021/acs.jproteome.2c00030

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9171846/
https://www.ncbi.nlm.nih.gov/pubmed/35536659
http://dx.doi.org/10.1021/acs.jproteome.2c00030

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