Discovery of novel SARS-CoV-2 inhibitors targeting the main protease M(pro) by virtual screenings and hit optimization

Two years after its emergence, SARS-CoV-2 still represents a serious and global threat to human health. Antiviral drug development usually takes a long time and, to increase the chances of success, chemical variability of hit compounds represents a valuable source for the discovery of new antivirals...

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Detalles Bibliográficos
Autores principales: Mercorelli, Beatrice, Desantis, Jenny, Celegato, Marta, Bazzacco, Alessandro, Siragusa, Lydia, Benedetti, Paolo, Eleuteri, Michela, Croci, Federico, Cruciani, Gabriele, Goracci, Laura, Loregian, Arianna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9172283/
https://www.ncbi.nlm.nih.gov/pubmed/35688349
http://dx.doi.org/10.1016/j.antiviral.2022.105350

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9172283/
https://www.ncbi.nlm.nih.gov/pubmed/35688349
http://dx.doi.org/10.1016/j.antiviral.2022.105350

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