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Mapping paratopes of nanobodies using native mass spectrometry and ultraviolet photodissociation

Following immense growth and maturity of the field in the past decade, native mass spectrometry has garnered widespread adoption for the structural characterization of macromolecular complexes. Routine analysis of biotherapeutics by this technique has become commonplace to assist in the development...

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Detalles Bibliográficos
Autores principales: Macias, Luis A., Wang, Xun, Davies, Bryan W., Brodbelt, Jennifer S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9172568/
https://www.ncbi.nlm.nih.gov/pubmed/35756525
http://dx.doi.org/10.1039/d2sc01536f