MITF deficiency accelerates GNAQ-driven uveal melanoma

Cutaneous melanoma (CM) and uveal melanoma (UM) both originate from the melanocytic lineage but are primarily driven by distinct oncogenic drivers, BRAF/NRAS or GNAQ/GNA11, respectively. The melanocytic master transcriptional regulator, MITF, is essential for both CM development and maintenance, but...

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Detalles Bibliográficos
Autores principales: Phelps, Grace B., Hagen, Hannah R., Amsterdam, Adam, Lees, Jacqueline A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9172632/
https://www.ncbi.nlm.nih.gov/pubmed/35512098
http://dx.doi.org/10.1073/pnas.2107006119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9172632/
https://www.ncbi.nlm.nih.gov/pubmed/35512098
http://dx.doi.org/10.1073/pnas.2107006119

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