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MITF deficiency accelerates GNAQ-driven uveal melanoma

Cutaneous melanoma (CM) and uveal melanoma (UM) both originate from the melanocytic lineage but are primarily driven by distinct oncogenic drivers, BRAF/NRAS or GNAQ/GNA11, respectively. The melanocytic master transcriptional regulator, MITF, is essential for both CM development and maintenance, but...

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Detalles Bibliográficos
Autores principales:	Phelps, Grace B., Hagen, Hannah R., Amsterdam, Adam, Lees, Jacqueline A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2022
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9172632/ https://www.ncbi.nlm.nih.gov/pubmed/35512098 http://dx.doi.org/10.1073/pnas.2107006119

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