Connectivity Mapping Using a Novel sv2a Loss-of-Function Zebrafish Epilepsy Model as a Powerful Strategy for Anti-epileptic Drug Discovery

Synaptic vesicle glycoprotein 2A (SV2A) regulates action potential-dependent neurotransmitter release and is commonly known as the primary binding site of an approved anti-epileptic drug, levetiracetam. Although several rodent knockout models have demonstrated the importance of SV2A for functional n...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Yifan, Heylen, Lise, Partoens, Michèle, Mills, James D., Kaminski, Rafal M., Godard, Patrice, Gillard, Michel, de Witte, Peter A. M., Siekierska, Aleksandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9172968/
https://www.ncbi.nlm.nih.gov/pubmed/35686059
http://dx.doi.org/10.3389/fnmol.2022.881933

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9172968/
https://www.ncbi.nlm.nih.gov/pubmed/35686059
http://dx.doi.org/10.3389/fnmol.2022.881933

Ejemplares similares