Cross-talk between mutant p53 and p62/SQSTM1 augments cancer cell migration by promoting the degradation of cell adhesion proteins

Missense mutations in the p53 tumor suppressor abound in human cancer. Common (“hotspot”) mutations endow mutant p53 (mutp53) proteins with oncogenic gain of function (GOF), including enhanced cell migration and invasiveness, favoring cancer progression. GOF is usually attributed to transcriptional...

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Detalles Bibliográficos
Autores principales: Mukherjee, Saptaparna, Maddalena, Martino, Lü, YiQing, Martinez, Sebastien, Nataraj, Nishanth Belugali, Noronha, Ashish, Sinha, Sansrity, Teng, Katie, Cohen-Kaplan, Victoria, Ziv, Tamar, Arandkar, Sharathchandra, Hassin, Ori, Chatterjee, Rishita, Pirona, Anna-Chiara, Shreberk-Shaked, Michal, Gershoni, Anat, Aylon, Yael, Elazar, Zvulun, Yarden, Yosef, Schramek, Daniel, Oren, Moshe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9173583/
https://www.ncbi.nlm.nih.gov/pubmed/35439056
http://dx.doi.org/10.1073/pnas.2119644119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9173583/
https://www.ncbi.nlm.nih.gov/pubmed/35439056
http://dx.doi.org/10.1073/pnas.2119644119

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