The catalytic mechanism of the mitochondrial methylenetetrahydrofolate dehydrogenase/cyclohydrolase (MTHFD2)

Methylenetetrahydrofolate dehydrogenase/cyclohydrolase (MTHFD2) is a new drug target that is expressed in cancer cells but not in normal adult cells, which provides an Achilles heel to selectively kill cancer cells. Despite the availability of crystal structures of MTHFD2 in the inhibitor- and cofac...

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Detalles Bibliográficos
Autores principales: Zhao, Li Na, Kaldis, Philipp
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9173628/
https://www.ncbi.nlm.nih.gov/pubmed/35613161
http://dx.doi.org/10.1371/journal.pcbi.1010140

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9173628/
https://www.ncbi.nlm.nih.gov/pubmed/35613161
http://dx.doi.org/10.1371/journal.pcbi.1010140

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