Mitochondrial metabolic reprogramming by SIRT3 regulation ameliorates drug resistance in renal cell carcinoma

Clear cell renal cell carcinoma (ccRCC) alters metabolic signals frequently, leading to mitochondrial dysfunction, such as increase of glycolysis and accumulation of lipid. Sirtuin3 (SIRT3) is a key factor for the regulation of both mitochondrial integrity and function. SIRT3 is downregulated and co...

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Detalles Bibliográficos
Autores principales: Gu, Young-Ran, Kim, Jinu, Na, Joon Chae, Han, Woong Kyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9173632/
https://www.ncbi.nlm.nih.gov/pubmed/35671305
http://dx.doi.org/10.1371/journal.pone.0269432

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9173632/
https://www.ncbi.nlm.nih.gov/pubmed/35671305
http://dx.doi.org/10.1371/journal.pone.0269432

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