Inhibition of the sodium-dependent HCO(3)(-) transporter SLC4A4, produces a cystic fibrosis-like airway disease phenotype

Bicarbonate secretion is a fundamental process involved in maintaining acid-base homeostasis. Disruption of bicarbonate entry into airway lumen, as has been observed in cystic fibrosis, produces several defects in lung function due to thick mucus accumulation. Bicarbonate is critical for correct muc...

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Detalles Bibliográficos
Autores principales: Saint-Criq, Vinciane, Guequén, Anita, Philp, Amber R, Villanueva, Sandra, Apablaza, Tábata, Fernández-Moncada, Ignacio, Mansilla, Agustín, Delpiano, Livia, Ruminot, Iván, Carrasco, Cristian, Gray, Michael A, Flores, Carlos A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9173743/
https://www.ncbi.nlm.nih.gov/pubmed/35635440
http://dx.doi.org/10.7554/eLife.75871

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9173743/
https://www.ncbi.nlm.nih.gov/pubmed/35635440
http://dx.doi.org/10.7554/eLife.75871

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