Autophagy in PDGFRα+ mesenchymal cells is essential for intestinal stem cell survival

Autophagy defects are a risk factor for inflammatory bowel diseases (IBDs) through unknown mechanisms. Whole-body conditional deletion of autophagy-related gene (Atg) Atg7 in adult mice (Atg7(Δ/Δ)) causes tissue damage and death within 3 mo due to neurodegeneration without substantial effect on inte...

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Detalles Bibliográficos
Autores principales: Yang, Yang, Gomez, Maria, Marsh, Timothy, Poillet-Perez, Laura, Sawant, Akshada, Chen, Lei, Park, Noel R., Jackson, S. RaElle, Hu, Zhixian, Alon, Noa, Liu, Chen, Debnath, Jayanta, Guan, Jun-Lin, Davidson, Shawn, Verzi, Michael, White, Eileen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9173755/
https://www.ncbi.nlm.nih.gov/pubmed/35537042
http://dx.doi.org/10.1073/pnas.2202016119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9173755/
https://www.ncbi.nlm.nih.gov/pubmed/35537042
http://dx.doi.org/10.1073/pnas.2202016119

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