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Autophagy in PDGFRα+ mesenchymal cells is essential for intestinal stem cell survival

Autophagy defects are a risk factor for inflammatory bowel diseases (IBDs) through unknown mechanisms. Whole-body conditional deletion of autophagy-related gene (Atg) Atg7 in adult mice (Atg7(Δ/Δ)) causes tissue damage and death within 3 mo due to neurodegeneration without substantial effect on inte...

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Detalles Bibliográficos
Autores principales:	Yang, Yang, Gomez, Maria, Marsh, Timothy, Poillet-Perez, Laura, Sawant, Akshada, Chen, Lei, Park, Noel R., Jackson, S. RaElle, Hu, Zhixian, Alon, Noa, Liu, Chen, Debnath, Jayanta, Guan, Jun-Lin, Davidson, Shawn, Verzi, Michael, White, Eileen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2022
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9173755/ https://www.ncbi.nlm.nih.gov/pubmed/35537042 http://dx.doi.org/10.1073/pnas.2202016119

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