H3K9 methylation drives resistance to androgen receptor–antagonist therapy in prostate cancer

Antiandrogen strategies remain the prostate cancer treatment backbone, but drug resistance develops. We show that androgen blockade in prostate cancer leads to derepression of retroelements (REs) followed by a double-stranded RNA (dsRNA)-stimulated interferon response that blocks tumor growth. A for...

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Detalles Bibliográficos
Autores principales: Baratchian, Mehdi, Tiwari, Ritika, Khalighi, Sirvan, Chakravarthy, Ankur, Yuan, Wei, Berk, Michael, Li, Jianneng, Guerinot, Amy, de Bono, Johann, Makarov, Vladimir, Chan, Timothy A., Silverman, Robert H., Stark, George R., Varadan, Vinay, De Carvalho, Daniel D., Chakraborty, Abhishek A., Sharifi, Nima
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9173765/
https://www.ncbi.nlm.nih.gov/pubmed/35584120
http://dx.doi.org/10.1073/pnas.2114324119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9173765/
https://www.ncbi.nlm.nih.gov/pubmed/35584120
http://dx.doi.org/10.1073/pnas.2114324119

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