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Congenital beta cell defects are not associated with markers of islet autoimmunity, even in the context of high genetic risk for type 1 diabetes

AIMS/HYPOTHESIS: A key unanswered question in type 1 diabetes is whether beta cells initiate their own destruction or are victims of an aberrant immune response (beta cell suicide or homicide?). To investigate this, we assessed islet autoantibodies in individuals with congenital beta cell defects ca...

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Detalles Bibliográficos
Autores principales: Wyatt, Rebecca C., Hagopian, William A., Roep, Bart O., Patel, Kashyap A., Resnick, Brittany, Dobbs, Rebecca, Hudson, Michelle, De Franco, Elisa, Ellard, Sian, Flanagan, Sarah E., Hattersley, Andrew T., Oram, Richard A., Johnson, Matthew B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9174109/
https://www.ncbi.nlm.nih.gov/pubmed/35501400
http://dx.doi.org/10.1007/s00125-022-05697-3