Cargando…

Congenital beta cell defects are not associated with markers of islet autoimmunity, even in the context of high genetic risk for type 1 diabetes

AIMS/HYPOTHESIS: A key unanswered question in type 1 diabetes is whether beta cells initiate their own destruction or are victims of an aberrant immune response (beta cell suicide or homicide?). To investigate this, we assessed islet autoantibodies in individuals with congenital beta cell defects ca...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wyatt, Rebecca C., Hagopian, William A., Roep, Bart O., Patel, Kashyap A., Resnick, Brittany, Dobbs, Rebecca, Hudson, Michelle, De Franco, Elisa, Ellard, Sian, Flanagan, Sarah E., Hattersley, Andrew T., Oram, Richard A., Johnson, Matthew B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2022
Materias:	Short Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9174109/ https://www.ncbi.nlm.nih.gov/pubmed/35501400 http://dx.doi.org/10.1007/s00125-022-05697-3

Ejemplares similares

Type 1 diabetes can present before the age of 6 months and is characterised by autoimmunity and rapid loss of beta cells
por: Johnson, Matthew B., et al.
Publicado: (2020)

Islet stress, degradation and autoimmunity
por: Thomaidou, Sofia, et al.
Publicado: (2018)

Neurogenin 3 is important but not essential for pancreatic islet development in humans
por: Rubio-Cabezas, Oscar, et al.
Publicado: (2014)

A type 1 diabetes genetic risk score can discriminate monogenic autoimmunity with diabetes from early-onset clustering of polygenic autoimmunity with diabetes
por: Johnson, Matthew B., et al.
Publicado: (2018)

Cellular Islet Autoimmunity Associates with Clinical Outcome of Islet Cell Transplantation
por: Huurman, Volkert A. L., et al.
Publicado: (2008)

Syndromic monogenic diabetes genes should be tested in patients with a clinical suspicion of MODY
por: Colclough, Kevin, et al.
Publicado: (2022)

Clinical and genetic correlates of islet-autoimmune signatures in juvenile-onset type 1 diabetes
por: Claessens, Laura A., et al.
Publicado: (2019)

Islet-Resident Dendritic Cells and Macrophages in Type 1 Diabetes: In Search of Bigfoot’s Print
por: Zirpel, Henner, et al.
Publicado: (2021)

Current Advances and Travails in Islet Transplantation
por: Harlan, David M., et al.
Publicado: (2009)

Comment on: Khurana et al. The Diagnosis of Neonatal Diabetes in a Mother at 25 Years of Age. Diabetes Care 2012;35:e59
por: Chakera, Ali J., et al.
Publicado: (2013)

A UK nationwide prospective study of treatment change in MODY: genetic subtype and clinical characteristics predict optimal glycaemic control after discontinuing insulin and metformin
por: Shepherd, Maggie H., et al.
Publicado: (2018)

IFNɣ but not IFNα increases recognition of insulin defective ribosomal product-derived antigen to amplify islet autoimmunity
por: Thomaidou, Sofia, et al.
Publicado: (2023)

β-Cells, Autoimmunity, and the Innate Immune System: “un Ménage á Trois”?
por: Roep, Bart O.
Publicado: (2013)

RET gene mutations are not a common cause of congenital solitary functioning kidney in adults
por: Oram, Richard A., et al.
Publicado: (2009)

PLIN1 Haploinsufficiency Is Not Associated With Lipodystrophy
por: Laver, Thomas W, et al.
Publicado: (2018)

Early Infant Diet and Islet Autoimmunity in the TEDDY Study
por: Uusitalo, Ulla, et al.
Publicado: (2018)

Metabolite-related dietary patterns and the development of islet autoimmunity
por: Johnson, Randi K., et al.
Publicado: (2019)

Autoimmunity in Autologous Islet Transplantation
por: Ali, Khawla F., et al.
Publicado: (2018)

GATA6 Mutations Cause a Broad Phenotypic Spectrum of Diabetes From Pancreatic Agenesis to Adult-Onset Diabetes Without Exocrine Insufficiency
por: De Franco, Elisa, et al.
Publicado: (2013)

SARS-CoV-2 — No Increased Islet Autoimmunity or Type 1 Diabetes in Teens
por: Krischer, Jeffrey P., et al.
Publicado: (2023)

Serum Cytokines as Biomarkers in Islet Cell Transplantation for Type 1 Diabetes
por: van der Torren, Cornelis R., et al.
Publicado: (2016)

Human islet T cells are highly reactive to preproinsulin in type 1 diabetes
por: Anderson, Amanda M., et al.
Publicado: (2021)

Syntaxin 4 Expression in Pancreatic β-Cells Promotes Islet Function and Protects Functional β-Cell Mass
por: Oh, Eunjin, et al.
Publicado: (2018)

Functional Impact of Risk Gene Variants on the Autoimmune Responses in Type 1 Diabetes
por: Gootjes, Chelsea, et al.
Publicado: (2022)

Mutations of the Same Conserved Glutamate Residue in NBD2 of the Sulfonylurea Receptor 1 Subunit of the K(ATP) Channel Can Result in Either Hyperinsulinism or Neonatal Diabetes
por: Männikkö, Roope, et al.
Publicado: (2011)

Neonatal diabetes caused by a homozygous KCNJ11 mutation demonstrates that tiny changes in ATP sensitivity markedly affect diabetes risk
por: Vedovato, Natascia, et al.
Publicado: (2016)

Atypical Forms of Congenital Hyperinsulinism in Infancy Are Associated With Mosaic Patterns of Immature Islet Cells
por: Han, Bing, et al.
Publicado: (2017)

Children’s erythrocyte fatty acids are associated with the risk of islet autoimmunity
por: Niinistö, Sari, et al.
Publicado: (2021)

Successful transfer to sulfonylureas in KCNJ11 neonatal diabetes is determined by the mutation and duration of diabetes
por: Babiker, Tarig, et al.
Publicado: (2016)

Diazoxide-unresponsive congenital hyperinsulinism associated with ABCC8 nonsense mutation
por: Hussain, Suhaimi, et al.
Publicado: (2015)

Islet autoimmunity in human type 1 diabetes: initiation and progression from the perspective of the beta cell
por: Thompson, Peter J., et al.
Publicado: (2023)

Graves Hyperthyroidism After Stopping Immunosuppressive Therapy in Type 1 Diabetic Islet Cell Recipients With Pretransplant TPO Autoantibodies
por: Gillard, Pieter, et al.
Publicado: (2009)

Erratum. Recessively Inherited LRBA Mutations Cause Autoimmunity Presenting as Neonatal Diabetes. Diabetes 2017;66:2316–2322
por: Johnson, Matthew B., et al.
Publicado: (2018)

Assessment of the HNF1B Score as a Tool to Select Patients for HNF1B Genetic Testing
por: Clissold, Rhian, et al.
Publicado: (2015)

Relative Frequency of Islet Autoimmunity in Children and Adolescents with Autoimmune Thyroid Disease
por: Putarek, Natasa Rojnic, et al.
Publicado: (2023)

Beta cell function and ongoing autoimmunity in long-standing, childhood onset type 1 diabetes
por: Williams, Georgina M., et al.
Publicado: (2016)

Evaluation of Evidence for Pathogenicity Demonstrates That BLK, KLF11, and PAX4 Should Not Be Included in Diagnostic Testing for MODY
por: Laver, Thomas W., et al.
Publicado: (2022)

Induction of tolerance to autoimmune diabetes with islet antigens
Publicado: (1992)

Regulation of T Follicular Helper Cells in Islet Autoimmunity
por: Serr, Isabelle, et al.
Publicado: (2018)

Etiology of Autoimmune Islet Disease: Timing Is Everything
por: Lernmark, Åke
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_3hv6kmne1cabfucseivlgueobh