Cargando…

Spatial expression of IKK-alpha is associated with a differential mutational landscape and survival in primary colorectal cancer

BACKGROUND: To understand the relationship between key non-canonical NF-κB kinase IKK-alpha(α), tumour mutational profile and survival in primary colorectal cancer. METHODS: Immunohistochemical expression of IKKα was assessed in a cohort of 1030 patients who had undergone surgery for colorectal canc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Patel, Meera, Pennel, Kathryn A. F., Quinn, Jean A., Hood, Hannah, Chang, David K., Biankin, Andrew V., Rebus, Selma, Roseweir, Antonia K., Park, James H., Horgan, Paul G., McMillan, Donald C., Edwards, Joanne
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9174220/ https://www.ncbi.nlm.nih.gov/pubmed/35173303 http://dx.doi.org/10.1038/s41416-022-01729-2

Ejemplares similares

CXCL8 expression is associated with advanced stage, right sidedness, and distinct histological features of colorectal cancer
por: Pennel, Kathryn AF, et al.
Publicado: (2022)

Spatially Resolved Transcriptomics Deconvolutes Prognostic Histological Subgroups in Patients with Colorectal Cancer and Synchronous Liver Metastases
por: Wood, Colin S., et al.
Publicado: (2023)

High expression of STAT3 within the tumour‐associated stroma predicts poor outcome in breast cancer patients
por: Morrow, Elizabeth, et al.
Publicado: (2023)

Reply to comment of “ERK and p38MAPK combine to improve survival in patients with BRAF mutant colorectal cancer”
por: Roseweir, Antonia K., et al.
Publicado: (2018)

Relationship between immune checkpoint proteins, tumour microenvironment characteristics, and prognosis in primary operable colorectal cancer
por: Al‐Badran, Sara SF, et al.
Publicado: (2020)

ERK and p38MAPK combine to improve survival in patients with BRAF mutant colorectal cancer
por: Roseweir, Antonia K., et al.
Publicado: (2018)

The Relationship Between Tumor Budding, Tumor Microenvironment, and Survival in Patients with Primary Operable Colorectal Cancer
por: van Wyk, Hester C., et al.
Publicado: (2019)

Relationship between tumour PTEN/Akt/COX-2 expression, inflammatory response and survival in patients with colorectal cancer
por: Roseweir, Antonia K., et al.
Publicado: (2016)

The Glasgow Microenvironment Score associates with prognosis and adjuvant chemotherapy response in colorectal cancer
por: Alexander, Peter G., et al.
Publicado: (2020)

The Glasgow Microenvironment Score and risk and site of recurrence in TNM I–III colorectal cancer
por: Alexander, P. G., et al.
Publicado: (2022)

Roles for the IKK-Related Kinases TBK1 and IKKε in Cancer
por: Durand, Joel K., et al.
Publicado: (2018)

Phosphorylation of androgen receptors at serine 515 is a potential prognostic marker for triple negative breast cancer
por: Roseweir, Antonia K., et al.
Publicado: (2017)

The relationship between members of the canonical NF-κB pathway, components of tumour microenvironment and survival in patients with invasive ductal breast cancer
por: Bennett, Lindsay, et al.
Publicado: (2017)

The relationship between right-sided tumour location, tumour microenvironment, systemic inflammation, adjuvant therapy and survival in patients undergoing surgery for colon and rectal cancer
por: Patel, Meera, et al.
Publicado: (2018)

Survivin-2B promotes autophagy by accumulating IKK alpha in the nucleus of selenite-treated NB4 cells
por: Shi, K, et al.
Publicado: (2014)

Histological phenotypic subtypes predict recurrence risk and response to adjuvant chemotherapy in patients with stage III colorectal cancer
por: Roseweir, Antonia K, et al.
Publicado: (2020)

The Relationship Between the Tumor Cell Expression of Hypoxic Markers and Survival in Patients With ER-positive Invasive Ductal Breast Cancer
por: Shamis, Suad A.K., et al.
Publicado: (2022)

Skyldig! - Ikke skyldig! /
por: Coppee, François, 1842-1908. [from old catalog]
Publicado: (1898)

Mismatch repair status in patients with primary operable colorectal cancer: associations with the local and systemic tumour environment
por: Park, James H, et al.
Publicado: (2016)

IKKα and IKKβ Regulation of DNA Damage-Induced Cleavage of Huntingtin
por: Khoshnan, Ali, et al.
Publicado: (2009)

The relationship between tumour budding, the tumour microenvironment and survival in patients with primary operable colorectal cancer
por: van Wyk, Hester C, et al.
Publicado: (2016)

Targeting IKKβ in Cancer: Challenges and Opportunities for the Therapeutic Utilisation of IKKβ Inhibitors
por: Prescott, Jack A., et al.
Publicado: (2018)

Defining the clinical genomic landscape for real-world precision oncology
por: Beer, Philip A., et al.
Publicado: (2020)

The relationship between carbonic anhydrase IX (CAIX) and patient survival in breast cancer: systematic review and meta-analysis
por: Shamis, Suad A. K., et al.
Publicado: (2023)

Preoperative, biopsy‐based assessment of the tumour microenvironment in patients with primary operable colorectal cancer
por: Park, James H, et al.
Publicado: (2019)

Expression of COX-2, NF-κB-p65, NF-κB-p50 and IKKα in malignant and adjacent normal human colorectal tissue
por: Charalambous, M P, et al.
Publicado: (2009)

Jorden går ikke under
Publicado: (2008)

An unexpected twist to the activation of IKKβ: TAK1 primes IKKβ for activation by autophosphorylation
por: Zhang, Jiazhen, et al.
Publicado: (2014)

TfR1 interacts with the IKK complex and is involved in IKK–NF-κB signalling
por: Kenneth, Niall S., et al.
Publicado: (2012)

Selective autophagic degradation of the IKK complex in Drosophila is mediated by Kenny/IKKγ to control inflammation
por: Jacomin, Anne-Claire, et al.
Publicado: (2019)

IKKβ is required for the formation of the NLRP3 inflammasome
por: Nanda, Sambit K, et al.
Publicado: (2021)

Protein expression of S100A2 reveals it association with patient prognosis and immune infiltration profile in colorectal cancer
por: Hatthakarnkul, Phimmada, et al.
Publicado: (2023)

Nuclear expression of Lyn, a Src family kinase member, is associated with poor prognosis in renal cancer patients
por: Roseweir, Antonia K., et al.
Publicado: (2016)

The IKK Kinases: Operators of Antiviral Signaling
por: Pham, Alissa M., et al.
Publicado: (2010)

Novel Phosphorylations of IKKγ/NEMO
por: Lee, Sun Hwa, et al.
Publicado: (2012)

Inhibitory-κB Kinase (IKK) α and Nuclear Factor-κB (NFκB)-Inducing Kinase (NIK) as Anti-Cancer Drug Targets
por: Paul, Andrew, et al.
Publicado: (2018)

The NEDD8 E3 ligase DCNL5 is phosphorylated by IKK alpha during Toll-like receptor activation
por: Thomas, Yann, et al.
Publicado: (2018)

The perioperative immune/inflammatory insult in cancer surgery: Time for intervention?
por: Roxburgh, Campbell S, et al.
Publicado: (2013)

Inhibition of IKKα by BAY61-3606 Reveals IKKα-Dependent Histone H3 Phosphorylation in Human Cytomegalovirus Infected Cells
por: Ho, Catherine M. K., et al.
Publicado: (2016)

Inflammatory related gene IKKα, IKKβ, IKKγ cooperates to determine liver cancer stem cells progression by altering telomere via heterochromatin protein 1-HOTAIR axis
por: An, Jiahui, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_ci0omaqd8r1nkg89rvpc9i6sti