High glutamine suppresses osteogenesis through mTORC1-mediated inhibition of the mTORC2/AKT-473/RUNX2 axis

Activation of the key nutrient cellular sensors mTORC1 and mTORC2 directs the fate of mesenchymal stromal cells (MSCs). Here, we report that glutamine regulates crosstalk between mTOR complexes and lineage commitment of MSCs independent of glucose concentration. High glutamine-induced mTORC1 hyperac...

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Detalles Bibliográficos
Autores principales: Gayatri, Meher Bolisetti, Gajula, Navya Naidu, Chava, Suresh, Reddy, Aramati B. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9174279/
https://www.ncbi.nlm.nih.gov/pubmed/35672290
http://dx.doi.org/10.1038/s41420-022-01077-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9174279/
https://www.ncbi.nlm.nih.gov/pubmed/35672290
http://dx.doi.org/10.1038/s41420-022-01077-3

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