Tizoxanide Promotes Apoptosis in Glioblastoma by Inhibiting CDK1 Activity

The antiparasitic drug nitazoxanide (NTZ) has received considerable attention for its potential in cancer therapy. In this study, we demonstrate that tizoxanide (TIZ), an active metabolite of NTZ, exhibits antiglioma activity in vitro and in vivo by inducing G2/M cell cycle arrest and apoptosis. In...

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Detalles Bibliográficos
Autores principales: Huang, Si, Xiao, Jingxian, Wu, Junyong, Liu, Jiayi, Feng, Xueping, Yang, Chengdong, Xiang, Daxiong, Luo, Shilin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9174573/
https://www.ncbi.nlm.nih.gov/pubmed/35694267
http://dx.doi.org/10.3389/fphar.2022.895573

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9174573/
https://www.ncbi.nlm.nih.gov/pubmed/35694267
http://dx.doi.org/10.3389/fphar.2022.895573

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