Direct C–H amination reactions of arenes with N-hydroxyphthalimides catalyzed by cuprous bromide

An efficient Cu-catalyzed strategy for the direct C–H amination of arenes in high yields using N-hydroxyphthalimide as the amidyl radical precursor under air is reported. A possible mechanism is proposed that proceeds via a radical reaction in the presence of CuBr and triethyl phosphite.

Detalles Bibliográficos
Autores principales: Zhang, Dongming, Lv, Bin, Gao, Pan, Jia, Xiaodong, Yuan, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2022
Materias:
Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9174840/
https://www.ncbi.nlm.nih.gov/pubmed/35706994
http://dx.doi.org/10.3762/bjoc.18.65
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author Zhang, Dongming
Lv, Bin
Gao, Pan
Jia, Xiaodong
Yuan, Yu
author_facet Zhang, Dongming
Lv, Bin
Gao, Pan
Jia, Xiaodong
Yuan, Yu
author_sort Zhang, Dongming
collection PubMed
description An efficient Cu-catalyzed strategy for the direct C–H amination of arenes in high yields using N-hydroxyphthalimide as the amidyl radical precursor under air is reported. A possible mechanism is proposed that proceeds via a radical reaction in the presence of CuBr and triethyl phosphite.
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spelling pubmed-91748402022-06-14 Direct C–H amination reactions of arenes with N-hydroxyphthalimides catalyzed by cuprous bromide Zhang, Dongming Lv, Bin Gao, Pan Jia, Xiaodong Yuan, Yu Beilstein J Org Chem Letter An efficient Cu-catalyzed strategy for the direct C–H amination of arenes in high yields using N-hydroxyphthalimide as the amidyl radical precursor under air is reported. A possible mechanism is proposed that proceeds via a radical reaction in the presence of CuBr and triethyl phosphite. Beilstein-Institut 2022-06-03 /pmc/articles/PMC9174840/ /pubmed/35706994 http://dx.doi.org/10.3762/bjoc.18.65 Text en Copyright © 2022, Zhang et al. https://creativecommons.org/licenses/by/4.0/This is an open access article licensed under the terms of the Beilstein-Institut Open Access License Agreement (https://www.beilstein-journals.org/bjoc/terms/terms), which is identical to the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/) ). The reuse of material under this license requires that the author(s), source and license are credited. Third-party material in this article could be subject to other licenses (typically indicated in the credit line), and in this case, users are required to obtain permission from the license holder to reuse the material.
spellingShingle Letter
Zhang, Dongming
Lv, Bin
Gao, Pan
Jia, Xiaodong
Yuan, Yu
Direct C–H amination reactions of arenes with N-hydroxyphthalimides catalyzed by cuprous bromide
title Direct C–H amination reactions of arenes with N-hydroxyphthalimides catalyzed by cuprous bromide
title_full Direct C–H amination reactions of arenes with N-hydroxyphthalimides catalyzed by cuprous bromide
title_fullStr Direct C–H amination reactions of arenes with N-hydroxyphthalimides catalyzed by cuprous bromide
title_full_unstemmed Direct C–H amination reactions of arenes with N-hydroxyphthalimides catalyzed by cuprous bromide
title_short Direct C–H amination reactions of arenes with N-hydroxyphthalimides catalyzed by cuprous bromide
title_sort direct c–h amination reactions of arenes with n-hydroxyphthalimides catalyzed by cuprous bromide
topic Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9174840/
https://www.ncbi.nlm.nih.gov/pubmed/35706994
http://dx.doi.org/10.3762/bjoc.18.65
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