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Anticancer Efficacy and Mechanisms of a Dual Targeting of Norepinephrine Transporter and Thyrointegrin αvβ3 Antagonist in Neuroblastoma

Background: In neuroendocrine tumors, the norepinephrine transporter (NET) is very active and has been exploited for diagnostic imaging purposes and/or therapy with localized radiotherapy. Integrin αvβ3 is generously expressed by and/or activated on cancer cells, but not by nonmalignant cells. Purpo...

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Detalles Bibliográficos
Autores principales: Godugu, Kavitha, Karakus, Ozlem O., Fujioka, Kazutoshi, Glinsky, Gennadi V., Mousa, Shaker A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9174855/
https://www.ncbi.nlm.nih.gov/pubmed/35711848
http://dx.doi.org/10.7150/jca.72522