Nanobodies dismantle post‐pyroptotic ASC specks and counteract inflammation in vivo

Inflammasomes sense intracellular clues of infection, damage, or metabolic imbalances. Activated inflammasome sensors polymerize the adaptor ASC into micron‐sized “specks” to maximize caspase‐1 activation and the maturation of IL‐1 cytokines. Caspase‐1 also drives pyroptosis, a lytic cell death char...

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Detalles Bibliográficos
Autores principales: Bertheloot, Damien, Wanderley, Carlos WS, Schneider, Ayda H, Schiffelers, Lisa DJ, Wuerth, Jennifer D, Tödtmann, Jan MP, Maasewerd, Salie, Hawwari, Ibrahim, Duthie, Fraser, Rohland, Cornelia, Ribeiro, Lucas S, Jenster, Lea‐Marie, Rosero, Nathalia, Tesfamariam, Yonas M, Cunha, Fernando Q, Schmidt, Florian I, Franklin, Bernardo S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9174887/
https://www.ncbi.nlm.nih.gov/pubmed/35438238
http://dx.doi.org/10.15252/emmm.202115415

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9174887/
https://www.ncbi.nlm.nih.gov/pubmed/35438238
http://dx.doi.org/10.15252/emmm.202115415

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