Cargando…

Comparative In vitro Metabolism of Enflicoxib in Dogs, Rats, and Humans: Main Metabolites and Proposed Metabolic Pathways

BACKGROUND: Enflicoxib is a non-steroidal anti-inflammatory drug of the coxib family characterized by a long-lasting pharmacological activity that has been attributed to its active metabolite E-6132. OBJECTIVES: The aim of this work was to explore enflicoxib biotransformation in vitro in humans, rat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Solà, Josep, Menargues, Àngel, Homedes, Josep, Salichs, Marta, Serafini, Maria Teresa, Encina, Gregorio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Bentham Science Publishers 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9175088/ https://www.ncbi.nlm.nih.gov/pubmed/34886785 http://dx.doi.org/10.2174/1872312814666211209161933

Ejemplares similares

Pharmacokinetics of enflicoxib in dogs: Effects of prandial state and repeated administration
por: Homedes, Josep, et al.
Publicado: (2021)

Selective inhibition of cyclooxygenase‐2 by enflicoxib, its enantiomers and its main metabolites in vitro in canine blood
por: Solà, Josep, et al.
Publicado: (2022)

Pharmacology of enflicoxib, a new coxib drug: Efficacy and dose determination by clinical and pharmacokinetic‐guided approach for the treatment of osteoarthritis in dogs based on an acute arthritis induction model
por: Cendrós, Josep‐Maria, et al.
Publicado: (2021)

Long-term safety evaluation of Daxocox(®) tablets (enflicoxib) in dogs after weekly oral administrations for seven months
por: Homedes, Josep, et al.
Publicado: (2021)

Evaluation of the Genotoxic Potential of the Selective COX-2 Inhibitor Enflicoxib in a Battery of in vitro and in vivo Genotoxicity Assays
por: Guzmán, Antonio, et al.
Publicado: (2022)

Enflicoxib for canine osteoarthritis: A randomized, blind, multicentre, non-inferiority clinical trial compared to mavacoxib
por: Salichs, Marta, et al.
Publicado: (2022)

A blinded, randomized and controlled multicenter clinical trial to assess the efficacy and safety of Leisguard(®) as an immunotherapeutic treatment for healthy Leishmania infantum-seropositive dogs
por: Baxarias, Marta, et al.
Publicado: (2023)

Use of preventive measures and serological screening tools for Leishmania infantum infection in dogs from Europe
por: Baxarias, Marta, et al.
Publicado: (2022)

Pharmacokinetics and Metabolism of Cyadox and Its Main Metabolites in Beagle Dogs Following Oral, Intramuscular, and Intravenous Administration
por: Sattar, Adeel, et al.
Publicado: (2016)

Metabolic Syndrome as a Cardiovascular Disease Risk Factor: Patients Evaluated in Primary Care
por: Cabré, Joan-Josep, et al.
Publicado: (2008)

Rheological Behavior of the A356 Alloy in the Semisolid State at Low Shear Rates
por: Martin-Raya, Oscar, et al.
Publicado: (2023)

Targeting the Metabolic Adaptation of Metastatic Cancer
por: Tarragó-Celada, Josep, et al.
Publicado: (2021)

Streptomyces and their specialised metabolites for phytopathogen control – comparative in vitro and in planta metabolic approaches
por: Dow, Lachlan, et al.
Publicado: (2023)

In Vitro Metabolic and Mitogenic Signaling of Insulin Glargine and Its Metabolites
por: Sommerfeld, Mark R., et al.
Publicado: (2010)

Obese dogs with and without obesity-related metabolic dysfunction – a proteomic approach
por: Tvarijonaviciute, Asta, et al.
Publicado: (2016)

Pharmacokinetics and Metabolism of Naringin and Active Metabolite Naringenin in Rats, Dogs, Humans, and the Differences Between Species
por: Bai, Yang, et al.
Publicado: (2020)

Plant Metabolites Affect Fusarium proliferatum Metabolism and In Vitro Fumonisin Biosynthesis
por: Lalak-Kańczugowska, Justyna, et al.
Publicado: (2023)

High concentrations of glucose reduce the oxidative metabolism of dog neutrophils in vitro
por: Bosco, Anelise M, et al.
Publicado: (2013)

Non-targeted metabolite profiling reveals changes in oxidative stress, tryptophan and lipid metabolisms in fearful dogs
por: Puurunen, Jenni, et al.
Publicado: (2016)

A Kinetic Study of the Main Guaco Metabolites Using Syrup Formulation and the Identification of an Alternative Route of Coumarin Metabolism in Humans
por: Gasparetto, João Cleverson, et al.
Publicado: (2015)

Secondary-metabolite biosynthesis and metabolism
por: Petroski, Richard, et al.
Publicado: (1992)

Metabolism, metabolites, and macrophages in cancer
por: Li, Mengyuan, et al.
Publicado: (2023)

Metabolic footprinting of extracellular metabolites of brain endothelium infected with Neospora caninum in vitro
por: Elsheikha, Hany M, et al.
Publicado: (2014)

Integrating systemic and molecular levels to infer key drivers sustaining metabolic adaptations
por: de Atauri, Pedro, et al.
Publicado: (2021)

Resveratrol, Metabolic Syndrome, and Gut Microbiota
por: Chaplin, Alice, et al.
Publicado: (2018)

Pharmacokinetics and Main Metabolites of Anwulignan in Mice
por: Chen, Cong, et al.
Publicado: (2022)

Edible Microalgae and Their Bioactive Compounds in the Prevention and Treatment of Metabolic Alterations
por: Ramos-Romero, Sara, et al.
Publicado: (2021)

In vitro human fecal microbial metabolism of Forsythoside A and biological activities of its metabolites
por: Xing, Shihua, et al.
Publicado: (2014)

Lipid Peroxidation, Nitric Oxide Metabolites, and Their Ratio in a Group of Subjects with Metabolic Syndrome
por: Caimi, Gregorio, et al.
Publicado: (2014)

Metabolic regulation and overproduction of primary metabolites
por: Sanchez, Sergio, et al.
Publicado: (2008)

Metabolite sensing and signaling in cell metabolism
por: Wang, Yi-Ping, et al.
Publicado: (2018)

Metabolite profiling during graft union formation reveals the reprogramming of primary metabolism and the induction of stilbene synthesis at the graft interface in grapevine
por: Prodhomme, Duyên, et al.
Publicado: (2019)

Unsustainability of Obesity: Metabolic Food Waste
por: Serafini, Mauro, et al.
Publicado: (2016)

Diabetes and obesity are the main metabolic drivers of peripheral neuropathy
por: Callaghan, Brian C., et al.
Publicado: (2018)

Obesity as the Main Risk Factor for Metabolic Syndrome in Children
por: Gepstein, Vardit, et al.
Publicado: (2019)

Different Diet Energy Levels Alter Body Condition, Glucolipid Metabolism, Fecal Microbiota and Metabolites in Adult Beagle Dogs
por: Sun, Haoran, et al.
Publicado: (2023)

Cardiac and Metabolic Variables in Obese Dogs
por: Tropf, M., et al.
Publicado: (2017)

Nutrition, Bioenergetics, and Metabolic Syndrome
por: García-García, Francesc Josep, et al.
Publicado: (2020)

Bismuth Redox Catalysis: An Emerging Main-Group Platform for Organic Synthesis
por: Moon, Hye Won, et al.
Publicado: (2022)

Lactate Beyond a Waste Metabolite: Metabolic Affairs and Signaling in Malignancy
por: Baltazar, Fátima, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_cq4rbumtg1a0s64og5aqg3rtpd