[4 + 2] and [2 + 4] cycloaddition reactions on single- and double-stranded DNA: a dual-reactive nucleoside

Here we report dual reactivity of diene-modified duplex DNA containing 5-(1,3-butadienyl)-2′-deoxyuridine “BDdU”. Normal-electron demand [4 + 2] cycloaddition proceeded upon addition of a maleimide, whereas inverse-electron demand [2 + 4] cycloaddition occurred upon addition of a tetrazine to give a...

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Detalles Bibliográficos
Autores principales: Bujalska, Anna, Basran, Kaleena, Luedtke, Nathan W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9175100/
https://www.ncbi.nlm.nih.gov/pubmed/35755194
http://dx.doi.org/10.1039/d2cb00062h

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9175100/
https://www.ncbi.nlm.nih.gov/pubmed/35755194
http://dx.doi.org/10.1039/d2cb00062h

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