The N-terminal autoinhibitory module of the A1 domain in von Willebrand factor stabilizes the mechanosensor catch bond

The von Willebrand factor (VWF), by interacting with the circulatory system and platelets, harnesses hemodynamic forces to form hemostatic plugs or occlusive thrombi. The autoinhibitory modules (AIMs) flanking the VWF-A1 domain were found to contribute to its biomechanical activation. However, how A...

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Detalles Bibliográficos
Autores principales: Zhao, Yunduo Charles, Wang, Haoqing, Wang, Yao, Lou, Jizhong, Ju, Lining Arnold
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9175105/
https://www.ncbi.nlm.nih.gov/pubmed/35755187
http://dx.doi.org/10.1039/d2cb00010e

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9175105/
https://www.ncbi.nlm.nih.gov/pubmed/35755187
http://dx.doi.org/10.1039/d2cb00010e

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