Fluorine-induced polarity increases inhibitory activity of BPTI towards chymotrypsin

Substituting the P(1) position in bovine pancreatic trypsin inhibitor (BPTI) is known to heavily influence its inhibitory activity towards serine proteases. Side-chain fluorinated aliphatic amino acids have been shown to alter numerous properties of peptides and proteins and thus are of interest in...

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Detalles Bibliográficos
Autores principales: Leppkes, Jakob, Dimos, Nicole, Loll, Bernhard, Hohmann, Thomas, Dyrks, Michael, Wieseke, Ariane, Keller, Bettina G., Koksch, Beate
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9175108/
https://www.ncbi.nlm.nih.gov/pubmed/35755190
http://dx.doi.org/10.1039/d2cb00018k

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9175108/
https://www.ncbi.nlm.nih.gov/pubmed/35755190
http://dx.doi.org/10.1039/d2cb00018k

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