Covalently attached intercalators restore duplex stability and splice-switching activity to triazole-modified oligonucleotides

Oligonucleotides are rapidly emerging as powerful therapeutics for hard to treat diseases. Short single-stranded oligonucleotides can base pair with target RNA and alter gene expression, providing an attractive therapeutic approach at the genetic level. Whilst conceptually appealing, oligonucleotide...

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Detalles Bibliográficos
Autores principales: Dysko, Anna, Baker, Ysobel R., McClorey, Graham, Wood, Matthew J. A., Fenner, Sabine, Williams, Glynn, El-Sagheer, Afaf, Brown, Tom
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9175110/
https://www.ncbi.nlm.nih.gov/pubmed/35755188
http://dx.doi.org/10.1039/d2cb00100d

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9175110/
https://www.ncbi.nlm.nih.gov/pubmed/35755188
http://dx.doi.org/10.1039/d2cb00100d

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