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Covalently attached intercalators restore duplex stability and splice-switching activity to triazole-modified oligonucleotides

Oligonucleotides are rapidly emerging as powerful therapeutics for hard to treat diseases. Short single-stranded oligonucleotides can base pair with target RNA and alter gene expression, providing an attractive therapeutic approach at the genetic level. Whilst conceptually appealing, oligonucleotide...

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Detalles Bibliográficos
Autores principales:	Dysko, Anna, Baker, Ysobel R., McClorey, Graham, Wood, Matthew J. A., Fenner, Sabine, Williams, Glynn, El-Sagheer, Afaf, Brown, Tom
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	RSC 2022
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9175110/ https://www.ncbi.nlm.nih.gov/pubmed/35755188 http://dx.doi.org/10.1039/d2cb00100d

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