The non-essential TSC complex component TBC1D7 restricts tissue mTORC1 signaling and brain and neuron growth

The tuberous sclerosis complex (TSC) 1 and 2 proteins associate with TBC1D7 to form the TSC complex, which is an essential suppressor of mTOR complex 1 (mTORC1), a ubiquitous driver of cell and tissue growth. Loss-of-function mutations in TSC1 or TSC2, but not TBC1D7, give rise to TSC, a pleiotropic...

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Detalles Bibliográficos
Autores principales: Schrötter, Sandra, Yuskaitis, Christopher J., MacArthur, Michael R., Mitchell, Sarah J., Hosios, Aaron M., Osipovich, Maria, Torrence, Margaret E., Mitchell, James R., Hoxhaj, Gerta, Sahin, Mustafa, Manning, Brendan D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9175135/
https://www.ncbi.nlm.nih.gov/pubmed/35584673
http://dx.doi.org/10.1016/j.celrep.2022.110824

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9175135/
https://www.ncbi.nlm.nih.gov/pubmed/35584673
http://dx.doi.org/10.1016/j.celrep.2022.110824

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