Live-cell microscopy or fluorescence anisotropy with budded baculoviruses—which way to go with measuring ligand binding to M(4) muscarinic receptors?

M(4) muscarinic acetylcholine receptor is a G protein-coupled receptor (GPCR) that has been associated with alcohol and cocaine abuse, Alzheimer's disease, and schizophrenia which makes it an interesting drug target. For many GPCRs, the high-affinity fluorescence ligands have expanded the optio...

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Detalles Bibliográficos
Autores principales: Tahk, Maris-Johanna, Torp, Jane, Ali, Mohammed A. S., Fishman, Dmytro, Parts, Leopold, Grätz, Lukas, Müller, Christoph, Keller, Max, Veiksina, Santa, Laasfeld, Tõnis, Rinken, Ago
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2022
Materias:
Methods and Techniques
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9175271/
https://www.ncbi.nlm.nih.gov/pubmed/35674179
http://dx.doi.org/10.1098/rsob.220019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9175271/
https://www.ncbi.nlm.nih.gov/pubmed/35674179
http://dx.doi.org/10.1098/rsob.220019

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