Single cell proteogenomic sequencing identifies a relapse‐fated AML subclone carrying FLT3‐ITD with CN‐LOH at chr13q

Internal tandem duplication of the Feline McDonough Sarcoma (FMS)‐like tyrosine kinase 3 (FLT3‐ITD) is one of the most clinically relevant mutations in acute myeloid leukemia (AML), with a high FLT3‐ITD allelic ratio (AR) (≥0.5) being strongly associated with poor prognosis. FLT3‐ITDs are heterogene...

Descripción completa

Detalles Bibliográficos
Autores principales: Kim, TaeHyung, Lee, Hyewon, Capo‐Chichi, Jose‐Mario, Chang, Myung Hee, Yoo, Young Seok, Basi, Gurbaksh, Ketela, Troy, Smith, Adam C., Tierens, Anne, Zhang, Zhaolei, Minden, Mark D., Kim, Dennis Dong Hwan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Haematologic Malignancy ‐ Myeloid
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9175792/
https://www.ncbi.nlm.nih.gov/pubmed/35846029
http://dx.doi.org/10.1002/jha2.390

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9175792/
https://www.ncbi.nlm.nih.gov/pubmed/35846029
http://dx.doi.org/10.1002/jha2.390

Ejemplares similares