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Single cell proteogenomic sequencing identifies a relapse‐fated AML subclone carrying FLT3‐ITD with CN‐LOH at chr13q

Internal tandem duplication of the Feline McDonough Sarcoma (FMS)‐like tyrosine kinase 3 (FLT3‐ITD) is one of the most clinically relevant mutations in acute myeloid leukemia (AML), with a high FLT3‐ITD allelic ratio (AR) (≥0.5) being strongly associated with poor prognosis. FLT3‐ITDs are heterogene...

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Detalles Bibliográficos
Autores principales:	Kim, TaeHyung, Lee, Hyewon, Capo‐Chichi, Jose‐Mario, Chang, Myung Hee, Yoo, Young Seok, Basi, Gurbaksh, Ketela, Troy, Smith, Adam C., Tierens, Anne, Zhang, Zhaolei, Minden, Mark D., Kim, Dennis Dong Hwan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Haematologic Malignancy ‐ Myeloid
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9175792/ https://www.ncbi.nlm.nih.gov/pubmed/35846029 http://dx.doi.org/10.1002/jha2.390

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