Decitabine mildly attenuates MLL‐rearranged acute lymphoblastic leukemia in vivo, and represents a poor chemo‐sensitizer

MLL‐rearranged acute lymphoblastic leukemia (ALL) represents a highly aggressive ALL subtype, characterized by aberrant DNA methylation patterns. DNA methyltransferase inhibitors, such as decitabine have previously been demonstrated to be effective in eradicating MLL‐rearranged ALL cells in vitro. H...

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Detalles Bibliográficos
Autores principales: Schneider, Pauline, Castro, Patricia Garrido, Pinhanços, Sandra M., Kerstjens, Mark, van Roon, Eddy H., Essing, Anke H.W., Dolman, M. Emmy M., Molenaar, Jan J., Pieters, Rob, Stam, Ronald W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Haematologic Malignancy ‐ Lymphoid
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9175850/
https://www.ncbi.nlm.nih.gov/pubmed/35844991
http://dx.doi.org/10.1002/jha2.81

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9175850/
https://www.ncbi.nlm.nih.gov/pubmed/35844991
http://dx.doi.org/10.1002/jha2.81

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