A mutant fibrinogen that is unable to form fibrin can improve renal phenotype in mice with sickle cell anemia

Sickle cell anemia (SCA) causes nephropathy which may progress to kidney failure. To determine if soluble fibrinogen (Fib(AEK)) can prevent kidney damage in mice with SCA, we performed bone marrow transplantation (BMT) of Berkeley sickle mice into wild‐type fibrinogen (Fib(WT)), and Fib(AEK) mice th...

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Detalles Bibliográficos
Autores principales: Narciso, Marilou G., Hoeting, Blair, James, Jeanne M., VandenHeuvel, Katherine, Nasimuzzaman, Md.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Short Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9176143/
https://www.ncbi.nlm.nih.gov/pubmed/35844706
http://dx.doi.org/10.1002/jha2.204

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9176143/
https://www.ncbi.nlm.nih.gov/pubmed/35844706
http://dx.doi.org/10.1002/jha2.204

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