Novel strategies for the mitigation of cytokine release syndrome induced by T cell engaging therapies with a focus on the use of kinase inhibitors

T cell engaging therapies, like CAR-T cells and T cell engagers, redirect T cells toward tumor cells, facilitating the formation of a cytotoxic synapse and resulting in subsequent tumor cell killing. T cell receptor or CAR-T downstream signaling triggers a release of pro-inflammatory cytokines, whic...

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Detalles Bibliográficos
Autores principales: Leclercq, Gabrielle, Steinhoff, Nathalie, Haegel, Hélène, De Marco, Donata, Bacac, Marina, Klein, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9176235/
https://www.ncbi.nlm.nih.gov/pubmed/35694193
http://dx.doi.org/10.1080/2162402X.2022.2083479

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9176235/
https://www.ncbi.nlm.nih.gov/pubmed/35694193
http://dx.doi.org/10.1080/2162402X.2022.2083479

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